The discovery of immune checkpoint inhibitors (ICIs) has now been universally
acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of …

The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted
through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein …

Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Tumorigenesis is not only determined by the intrinsic properties of cancer cells but also by
their interactions with components of the tumor microenvironment (TME). Tumor‐associated …

Background Even though exosome-based therapy has been shown to be able to control the
progression of different pathologies, the data revealed by pharmacokinetic studies warn of …

Background T cell checkpoint immunotherapies have shown promising results in the clinic,
but most patients remain non-responsive. CD47-signal regulatory protein alpha (SIRPα) …

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Background Both innate and adaptive immune responses are important components of
anticancer immunity. The CD47–SIRPα interaction could represent an important pathway …

Erythropoiesis is a highly regulated process where sequential events ensure the proper
differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs) …