Fig 2. Classification of granules in neutrophils. Peroxidase-positive (azurophilic or primary)
granules are characterized by the content of MPO and may be further divided based on their …

Secretory granules are specialized intracellular organelles that serve as a storage pool for
selected secretory products. The exocytosis of secretory granules is markedly amplified …

Many peptide hormones are produced from larger precursors by endoproteolysis at pairs of
basic amino acids (eg Lys-Arg and Arg-Arg) within the regulated secretory pathway in …

It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin
secretion is the essential element in the progression of patients from a state of impaired …

Nerve growth factor (NGF) is released through the constitutive secretory pathway from cells
in peripheral tissues and nerves where it can act as a target-derived survival factor. In …

Regulated secretory proteins are thought to be sorted in the trans-Golgi network (TGN) via
selective aggregation. The factors responsible for this aggregation are unknown. We show …

A proposed mechanism for sorting secretory proteins into granules for release via the
regulated secretory pathway in endocrine-neuroendocrine cells involves binding the …

Electron micrograph is taken from Rambourg and Clermont (1990) with permission. The
trans side is recognizable by maturing (Pg) and mature (g) secretory granules. The …

Endothelial cells store the multimeric adhesive glycoprotein von Willebrand factor (vWf),
which promotes the formation of a platelet plug at the site of vessel injury. To investigate the …

Secretory granule formation requires selection of soluble and membrane proteins into
nascent secretory granules, and exclusion of proteins not required for the function of …