Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …

Allogeneic haematopoietic stem-cell transplantation (SCT) is a curative therapy for
haematological malignancies and inherited disorders of blood cells, such as sickle-cell …

Next-generation sequencing of the hypervariable V3 region of the 16s rRNA gene isolated
from serial stool specimens collected from 31 patients receiving allogeneic stem cell …

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective
adoptive cellular immunotherapy for the treatment of a number of cancers. The …

Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment
of acute graft-versus-host disease (aGVHD) have been translated from the bench to the …

Dendritic cells (DCs) are a heterogeneous fraction of rare hematopoietic cells that coevolved
with the formation of the adaptive immune system. DCs efficiently process and present …

In acute graft-versus-host disease (GVHD), naive donor CD4+ T cells recognize alloantigens
on host antigen-presenting cells and differentiate into T helper (Th) subsets (Th1, Th2, and …

The last 6 decades have seen major advances in the understanding of immunologic
diseases, driven by preclinical animal models. Indeed, bone marrow transplantation (BMT) …

During the past decade, progress in basic immunology has been impressive. In parallel,
whereas our understanding of the pathophysiology of acute graft-versus-host disease …

Langerhans cells (LC) are a unique population of tissue-resident macrophages that form a
network of cells across the epidermis of the skin, but which have the ability to migrate from …