Interpreting the BOLD signal
NK Logothetis, BA Wandell - Annu. Rev. Physiol., 2004 - annualreviews.org
▪ Abstract The development of functional magnetic resonance imaging (fMRI) has brought
together a broad community of scientists interested in measuring the neural basis of the …
together a broad community of scientists interested in measuring the neural basis of the …
In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
▪ Abstract Until very recently, non-invasive measurement of the glutamate-glutamine cycle in
the intact mammalian brain had not been possible. In this review, we describe some studies …
the intact mammalian brain had not been possible. In this review, we describe some studies …
Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI
AJ Smith, H Blumenfeld, KL Behar… - Proceedings of the …, 2002 - National Acad Sciences
Functional MRI (fMRI) is widely assumed to measure neuronal activity, but no satisfactory
mechanism for this linkage has been identified. Here we derived the changes in the …
mechanism for this linkage has been identified. Here we derived the changes in the …
Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
The spatial extent of the changes in oxy-hemoglobin (HbO), deoxy-hemoglobin (HbR), total
hemoglobin concentration (HbT), cerebral blood flow (CBF), and the cerebral metabolic rate …
hemoglobin concentration (HbT), cerebral blood flow (CBF), and the cerebral metabolic rate …
Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging
RG Shulman, F Hyder… - Proceedings of the …, 2001 - National Acad Sciences
Positron-emission tomography and functional MRS imaging signals can be analyzed to
derive neurophysiological values of cerebral blood flow or volume and cerebral metabolic …
derive neurophysiological values of cerebral blood flow or volume and cerebral metabolic …
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI
Quantitative magnetic resonance imaging (MRI) and spectroscopy (MRS) measurements of
energy metabolism (ie cerebral metabolic rate of oxygen consumption, CMRO2), blood …
energy metabolism (ie cerebral metabolic rate of oxygen consumption, CMRO2), blood …
Negative BOLD with large increases in neuronal activity
U Schridde, M Khubchandani, JE Motelow… - Cerebral …, 2008 - academic.oup.com
Blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI) is
widely used in neuroscience to study brain activity. However, BOLD fMRI does not measure …
widely used in neuroscience to study brain activity. However, BOLD fMRI does not measure …
A vascular anatomical network model of the spatio-temporal response to brain activation
Neuronal activity-induced changes in vascular tone and oxygen consumption result in a
dynamic evolution of blood flow, volume, and oxygenation. Functional neuroimaging …
dynamic evolution of blood flow, volume, and oxygenation. Functional neuroimaging …
Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI
F Hyder, DL Rothman… - Proceedings of the …, 2002 - National Acad Sciences
In α-chloralose-anesthetized rats, changes in the blood oxygenation level-dependent
(BOLD) functional MRI (fMRI) signal (ΔS/S), and the relative spiking frequency of a neuronal …
(BOLD) functional MRI (fMRI) signal (ΔS/S), and the relative spiking frequency of a neuronal …
From molecules to networks: cortical/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy
H Blumenfeld - Epilepsia, 2003 - Wiley Online Library
Generalized epilepsy involves abnormally synchronized activity in large‐scale neuronal
networks. Burst firing of action potentials is a potent mechanism for increasing neural …
networks. Burst firing of action potentials is a potent mechanism for increasing neural …