The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …

The recent years have witnessed a dramatic increase in the use of reinforcement learning
(RL) models in social, cognitive and affective neuroscience. This approach, in combination …

The brain faces various computational tradeoffs, such as the stability-flexibility dilemma. The
major ascending neuromodulatory systems are well suited to dynamically regulate these …

Mood is an integrative and diffuse affective state that is thought to exert a pervasive effect on
cognition and behavior. At the same time, mood itself is thought to fluctuate slowly as a …

Flexible behavior is critical for everyday decision-making and has been implicated in
restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how …

Perceived control can be broadly defined as the belief in one's ability to exert control over
situations or events. It has long been known that perceived control is a major contributor …

A Pavlovian bias to approach reward-predictive cues and avoid punishment-predictive cues
can conflict with instrumentally-optimal actions. Here, we propose that the brain arbitrates …

Effort-related decision-making and reward learning are both dopamine-dependent, but
preclinical research suggests they depend on different dopamine signaling dynamics …

Individual differences in striatal dopamine synthesis capacity have been associated with
working memory capacity, trait impulsivity, and spontaneous eye-blink rate (sEBR), as …