Glutamate and dopamine in schizophrenia: An update for the 21st century
O Howes, R McCutcheon… - Journal of …, 2015 - journals.sagepub.com
The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
A pathophysiological framework of hippocampal dysfunction in ageing and disease
The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …
[HTML][HTML] Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
Characterizing dynamic amplitude of low-frequency fluctuation and its relationship with dynamic functional connectivity: an application to schizophrenia
The human brain is a highly dynamic system with non-stationary neural activity and rapidly-
changing neural interaction. Resting-state dynamic functional connectivity (dFC) has been …
changing neural interaction. Resting-state dynamic functional connectivity (dFC) has been …
The hippocampal formation in schizophrenia
CA Tamminga, AD Stan… - American Journal of …, 2010 - Am Psychiatric Assoc
The hippocampal formation is one of the most extensively studied regions of the brain, with
well-described anatomy and basic physiology; moreover, aspects of human memory …
well-described anatomy and basic physiology; moreover, aspects of human memory …
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …
neurotransmitter interactions have been implicated. We have developed a circuit-based …
GABAergic mechanisms of hippocampal hyperactivity in schizophrenia
Schizophrenia is associated with abnormalities of hippocampal structure and function.
Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia …
Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia …
Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week …
MH Zhu, ZJ Liu, QY Hu, JY Yang, Y Jin, N Zhu… - Military Medical …, 2022 - Springer
Background Although clozapine is an effective option for treatment-resistant schizophrenia
(TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main …
(TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main …
[HTML][HTML] Sex differences in the blood–brain barrier: implications for mental health
Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …