Additive manufacturing technologies: 3D printing in organic synthesis

S Rossi, A Puglisi, M Benaglia - ChemCatChem, 2018 - Wiley Online Library
The manufacturing of a three‐dimensional product from a computer‐driven digital model (3D
printing) has found extensive applications in several fields. Additive manufacturing …

Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes

AAH Laporte, TM Masson, SDA Zondag… - Angewandte …, 2024 - Wiley Online Library
The use of reactive gaseous reagents for the production of active pharmaceutical
ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The …

Bayesian optimization of computer-proposed multistep synthetic routes on an automated robotic flow platform

AMK Nambiar, CP Breen, T Hart, T Kulesza… - ACS Central …, 2022 - ACS Publications
Computer-aided synthesis planning (CASP) tools can propose retrosynthetic pathways and
forward reaction conditions for the synthesis of organic compounds, but the limited …

Advanced real‐time process analytics for multistep synthesis in continuous flow

P Sagmeister, R Lebl, I Castillo, J Rehrl… - Angewandte Chemie …, 2021 - Wiley Online Library
In multistep continuous flow chemistry, studying complex reaction mixtures in real time is a
significant challenge, but provides an opportunity to enhance reaction understanding and …

3D printing in heterogeneous catalysis—the state of the art

E Bogdan, P Michorczyk - Materials, 2020 - mdpi.com
This paper describes the process of additive manufacturing and a selection of three-
dimensional (3D) printing methods which have applications in chemical synthesis …

Application of reactor engineering concepts in continuous flow chemistry: a review

NC Neyt, DL Riley - Reaction Chemistry & Engineering, 2021 - pubs.rsc.org
The adoption of flow technology for the manufacture of chemical entities, and in particular
pharmaceuticals, has seen rapid growth over the past two decades with the technology now …

3D‐printed structured reactor with integrated single‐atom catalyst film for hydrogenation

G Vilé, D Ng, Z Xie, I Martinez‐Botella… - …, 2022 - Wiley Online Library
Structured catalytic reactors are gaining considerable attention for integrated chemical
synthesis because they offer enhanced mass transfer and easy catalyst recovery. In this …

Continuous flow hydrogenation of flavorings and fragrances using 3D-printed catalytic static mixers

M Kundra, T Grall, D Ng, Z Xie… - Industrial & Engineering …, 2021 - ACS Publications
A new type of additively manufactured catalytic static mixer, coated with alumina-supported
metal catalysts, has been used for the hydrogenation of various model compounds …

[HTML][HTML] 3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries

CR Sagandira, M Siyawamwaya, P Watts - Arabian Journal of Chemistry, 2020 - Elsevier
The realization of a downward spiralling of diseases in developing countries requires them
to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by …

[HTML][HTML] Scalable continuous flow hydrogenations using Pd/Al2O3-coated rectangular cross-section 3D-printed static mixers

R Lebl, Y Zhu, D Ng, CH Hornung, D Cantillo… - Catalysis Today, 2022 - Elsevier
A novel type of catalytic static mixers with rectangular cross-section coated with Pd/Al 2 O 3
has been developed. The catalytic mixers, produced by additive manufacturing and coated …