Histiocytic disorders

KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Langerhans cell histiocytosis

C Rodriguez-Galindo, CE Allen - Blood, The Journal of the …, 2020 - ashpublications.org
Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors
that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ …

International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults

G Goyal, A Tazi, RS Go, KL Rech… - Blood, The Journal …, 2022 - ashpublications.org
Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

Histiocytosis

JF Emile, F Cohen-Aubart, M Collin, S Fraitag, A Idbaih… - The Lancet, 2021 - thelancet.com
Histiocytoses constitute a heterogeneous group of rare disorders, characterised by
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …

Histiocytic neoplasms, version 2.2021, NCCN clinical practice guidelines in oncology

RS Go, E Jacobsen, R Baiocchi, I Buhtoiarov… - Journal of the National …, 2021 - jnccn.org
Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …

Long-term outcomes among adults with Langerhans cell histiocytosis

G Goyal, AA Acosta-Medina, JP Abeykoon… - Blood …, 2023 - ashpublications.org
Advances in the treatment of Langerhans cell histiocytosis (LCH) have resulted in a growing
survivor population. There is a lack of data on long-term outcomes among adults with LCH …

Update on pulmonary Langerhans cell histiocytosis

E Radzikowska - Frontiers in Medicine, 2021 - frontiersin.org
Pulmonary Langerhans cell (LC) histiocytosis (PLCH) has unknown cause and is a rare
neoplastic disorder characterized by the infiltration of lungs and various organs by bone …

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation

PG Kemps, KM Hebeda, ST Pals… - The Journal of …, 2021 - Wiley Online Library
Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation of
macrophage‐, dendritic cell‐, or monocyte‐differentiated cells in various tissues and organs …

Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies

J Ma, JH Laird, KW Chau, MR Chelius, BH Lok… - Cancer …, 2019 - Wiley Online Library
Background Langerhans cell histiocytosis (LCH) is a rare disorder of histiocyte proliferation.
Previous case studies suggest a higher prevalence of hematologic and solid malignancies …

Treatment of Langerhans cell histiocytosis and histiocytic disorders: a focus on MAPK pathway inhibitors

AV Geerlinks, O Abla - Pediatric Drugs, 2023 - Springer
Histiocytic disorders are rare diseases defined by the clonal accumulation of a macrophage
or dendritic cell origin. These disorders include Langerhans cell histiocytosis, Erdheim …