International Union of Basic and Clinical Pharmacology. CV. Somatostatin receptors: structure, function, ligands, and new nomenclature
T Günther, G Tulipano, P Dournaud, C Bousquet… - Pharmacological …, 2018 - Elsevier
Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
PDZ domains as drug targets
NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …
often is promoted by specialized protein interaction modules, such as the postsynaptic …
Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity
Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction
compartments responsible for signal processing in each and every neuron. Proper formation …
compartments responsible for signal processing in each and every neuron. Proper formation …
Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity
Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched
cellular compartments beneath postsynaptic membranes, which constantly exchange their …
cellular compartments beneath postsynaptic membranes, which constantly exchange their …
Phosphorylation-dependent membraneless organelle fusion and fission illustrated by postsynaptic density assemblies
Membraneless organelles formed by phase separation of proteins and nucleic acids play
diverse cellular functions. Whether and, if yes, how membraneless organelles in ways …
diverse cellular functions. Whether and, if yes, how membraneless organelles in ways …
Mechanisms of endocannabinoid control of synaptic plasticity
BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation
Abstract Ca2+/calmodulin-dependent kinase IIα (CaMKIIα) is essential for synaptic plasticity
and learning by decoding synaptic Ca2+ oscillations. Despite decades of extensive …
and learning by decoding synaptic Ca2+ oscillations. Despite decades of extensive …
Phase separation-mediated TARP/MAGUK complex condensation and AMPA receptor synaptic transmission
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) modulate AMPAR
synaptic trafficking and transmission via disc-large (DLG) subfamily of membrane …
synaptic trafficking and transmission via disc-large (DLG) subfamily of membrane …
Phase separation as a mechanism for assembling dynamic postsynaptic density signalling complexes
Highlights•Superresolution studies demonstrated nanodomain-like organization within
postsynaptic densities.•Purified PSD scaffold proteins phase separate in vitro and in living …
postsynaptic densities.•Purified PSD scaffold proteins phase separate in vitro and in living …
IRSp53 promotes postsynaptic density formation and actin filament bundling
IRSp53 (aka BAIAP2) is a scaffold protein that couples membranes with the cytoskeleton in
actin-filled protrusions such as filopodia and lamellipodia. The protein is abundantly …
actin-filled protrusions such as filopodia and lamellipodia. The protein is abundantly …