Abstract Introduction: The American Thyroid Association appointed a Task Force of experts
to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the …

Context: Over the last decade, our knowledge of the multiple endocrine neoplasia (MEN)
type 2 syndromes MEN2A and MEN2B and familial medullary thyroid carcinoma (FMTC) has …

Germline inactivating mutations of isoform 4 of phosphodiesterase (PDE) 11A (coded by the
PDE11A gene) have been associated with familial adrenocortical tumors and familial …

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are catecholamine-secreting
tumors of neural crest origin. Once collectively known as the '10% tumor', based on the …

Simple Summary The post-surgical treatment of atypical meningiomas is controversial in
cases with gross total resection, because one out of two patients develops disease …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …

Background Medullary thyroid cancer (MTC) is a rare thyroid cancer accounting for 5% of all
thyroid malignancies. The purpose of our study was to design a predictive nomogram for …

Multiple endocrine neoplasia type 2 (MEN2) is a neuroendocrine cancer syndrome
characterized by medullary thyroid carcinoma, in combination or not with …

Whole-exome sequencing has emerged as a fast and effective tool for the elucidation of
genetic defects underlying both rare and common human diseases. Increased availability …

Receptor tyrosine kinases (RTKs) are transmembrane proteins involved in the control of
fundamental cellular processes in metazoans. RTKs possess a general structure that …