Genetics of multiple sclerosis: an overview and new directions
NA Patsopoulos - Cold Spring Harbor …, 2018 - perspectivesinmedicine.cshlp.org
The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …
Applications of deep learning in understanding gene regulation
Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …
accumulation of omics data have provided better opportunities for gene regulation studies …
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease
The gene-regulatory landscape of the brain is highly dynamic in health and disease,
coordinating a menagerie of biological processes across distinct cell types. Here, we …
coordinating a menagerie of biological processes across distinct cell types. Here, we …
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium*†… - Science, 2019 - science.org
INTRODUCTION Multiple sclerosis (MS) is an inflammatory and degenerative disease of the
central nervous system (CNS) that often presents in young adults. Over the past decade …
central nervous system (CNS) that often presents in young adults. Over the past decade …
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
NYA Sey, B Hu, W Mah, H Fauni, JC McAfee… - Nature …, 2020 - nature.com
Most risk variants for brain disorders identified by genome-wide association studies reside in
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells
M Zhao, P Chauhan, CA Sherman, A Singh… - Nature …, 2023 - nature.com
The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-
induced gene expression in diverse cell types. Cellular responses to NF-κB activation are …
induced gene expression in diverse cell types. Cellular responses to NF-κB activation are …
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection
AK Hedström - Frontiers in Immunology, 2023 - frontiersin.org
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …
Development of autoantibodies precedes clinical manifestations of autoimmune diseases: a comprehensive review
WT Ma, C Chang, ME Gershwin, ZX Lian - Journal of autoimmunity, 2017 - Elsevier
The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …
environmental factors that alter the expression of immune regulatory genes through various …