Recent imaging studies show that the formation of neural connections in the central nervous
system is a highly dynamic process. The iterative formation and elimination of synapses and …

In the past 15 years numerous reports provided strong evidence that brain-derived
neurotrophic factor (BDNF) is one of the most important modulators of glutamatergic and …

The neurotrophins are best known for their ability to support neuronal survival and
differentiation, but a role in synapse formation and plasticity has recently emerged. For …

It has been suggested that long-term modifications of synaptic transmission constitute the
foundation of the processes by which information is stored in the central nervous system. A …

Brain-derived neurotrophic factor (BDNF) has been implicated in activity-dependent
plasticity of neuronal function and network arrangement. To clarify how BDNF exerts its …

The results of several studies have contributed to the hypothesis that BDNF promotes
seizure activity, particularly in adult hippocampus. To test this hypothesis, BDNF, vehicle …

Neurons of the vertebrate central nervous system have the capacity to modify synapse
number, morphology, and efficacy in response to activity. Some of these functions can be …

Recent studies have implicated the hormone leptin in synaptic plasticity associated with
neuronal development and learning and memory. Indeed, leptin facilitates hippocampal …

Abstract Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation,
maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of …

In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for
several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can …