Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

There are 425 million people with diabetes mellitus in the world. By 2045, this figure will
grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases …

Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II
diabetes (T2D), an epidemic afflicting nearly 10% of the world's population. To visualize …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Autophagy is essential in regulating the turnover of macromolecules via removing damaged
organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and …

The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and
hampers the widespread application of this powerful class of therapeutic agents. In that …

Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …

Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …