T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

Nitric oxide (NO) has been shown to regulate T cell functions under physiological conditions,
but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue …

CD38 has emerged as a potential therapeutic target for patients with systemic lupus
erythematosus (SLE) but it is not known whether CD38 alters CD4+ T cell function. Using …

We investigated the role of the costimulatory molecules, CD40 and its ligand CD40L, in the
pathogenesis of human SLE. In comparison to normal subjects or patients in remission …

Objective Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown
origin. Current treatment options are often ineffective or poorly tolerated. Recent …

Cellular immunity aberrations in patients with SLE are underscored by the abnormal early
Ag receptor-mediated lymphocyte signal transduction pathway. To further characterize the T …

Persistent mitochondrial hyperpolarization (MHP) and enhanced calcium fluxing underlie
aberrant T cell activation and death pathway selection in systemic lupus erythematosus …

EBV infection is more common in patients with systemic lupus erythematosus (SLE) than in
control subjects, suggesting that this virus plays an etiologic role in disease and/or that …

Objective Previous studies have shown that inhibiting T cell DNA methylation causes a
lupus‐like disease by modifying gene expression. T cells from patients with lupus exhibit …

Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element
modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 …