Objective To assess the effect of tranexamic acid on blood transfusion, thromboembolic
events, and mortality in surgical patients. Design Systematic review and meta-analysis. Data …

Tranexamic acid, a synthetic derivative of the amino acid lysine, is an antifibrinolytic agent
that acts by binding to plasminogen and blocking the interaction of plasmin (ogen) with …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a
major challenge in the management of both surgical and seriously injured patients. Under …

Background Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of
the reduction in blood loss and how it relates to the dose of TXA is unclear. Methods A …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Pediatric cardiac surgery is associated with a substantial risk of bleeding, frequently
requiring the administration of allogeneic blood products. Efforts to optimize preoperative …

Background Surgical correction of craniosynostosis in children is associated with substantial
intraoperative bleeding. Tranexamic acid (TXA) decreases intraoperative blood loss during …

Objective: Aprotinin reduces the blood loss and transfusion of blood products in children
undergoing major surgery. Aprotinin has been associated with severe side effects in adults …

BACKGROUND Tranexamic acid (TXA) is an inexpensive therapy effective at minimizing
perioperative blood loss and transfusion. However, it remains underutilized due to safety …