Aberrant gene expression that drives human cancer can arise from epigenetic
dysregulation. Although much attention has focused on altered activity of transcription …

The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …

Local invasion and distant metastasis are the key hallmarks in the aggressive progression of
malignant tumors, including the ability of cancer cells to detach from the extracellular matrix …

Motivation Global analysis of translation regulation has recently been enabled by the
development of Ribosome Profiling, or Ribo-seq, technology. This approach provides maps …

The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell
fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a …

During neuronal differentiation, the transcriptional profile and the epigenetic context of
neural committed cells is subject to significant rearrangements, but a systematic …

The microRNA (miRNA)-200 (miR-200) family is highly expressed in epithelial cells and
frequently lost in metastatic cancer. Despite intensive studies into their roles in cancer, their …

Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the
regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been …

Background Although previous studies have shown promise for targeting Musashi RNA-
binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical …

Progression of chronic lymphocytic leukemia (CLL) results from the expansion of a small
fraction of proliferating leukemic B cells. When comparing the global gene expression of …