Insect resistance to Bt crops: lessons from the first billion acres

BE Tabashnik, T Brévault, Y Carrière - Nature biotechnology, 2013 - nature.com
Evolution of resistance in pests can reduce the effectiveness of insecticidal proteins from
Bacillus thuringiensis (Bt) produced by transgenic crops. We analyzed results of 77 studies …

Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Optimizing pyramided transgenic Bt crops for sustainable pest management

Y Carrière, N Crickmore, BE Tabashnik - Nature biotechnology, 2015 - nature.com
Transgenic crop pyramids producing two or more Bacillus thuringiensis (Bt) toxins that kill
the same insect pest have been widely used to delay evolution of pest resistance. To assess …

Field-evolved resistance to Bt maize by western corn rootworm

AJ Gassmann, JL Petzold-Maxwell, RS Keweshan… - PloS one, 2011 - journals.plos.org
Background Crops engineered to produce insecticidal toxins derived from the bacterium
Bacillus thuringiensis (Bt) are planted on millions of hectares annually, reducing the use of …

Defining terms for proactive management of resistance to Bt crops and pesticides

BE Tabashnik, D Mota-Sanchez… - Journal of economic …, 2014 - academic.oup.com
Evolution of pest resistance to pesticides is an urgent global problem with resistance
recorded in at least 954 species of pests, including 546 arthropods, 218 weeds, and 190 …

Can pyramids and seed mixtures delay resistance to Bt crops?

Y Carrière, JA Fabrick, BE Tabashnik - Trends in biotechnology, 2016 - cell.com
The primary strategy for delaying the evolution of pest resistance to transgenic crops that
produce insecticidal proteins from Bacillus thuringiensis (Bt) entails refuges of plants that do …

An ABC Transporter Mutation Is Correlated with Insect Resistance to Bacillus thuringiensis Cry1Ac Toxin

LJ Gahan, Y Pauchet, H Vogel, DG Heckel - PLoS genetics, 2010 - journals.plos.org
Transgenic crops producing insecticidal toxins from Bacillus thuringiensis (Bt) are
commercially successful in reducing pest damage, yet knowledge of resistance mechanisms …

Success of the high‐dose/refuge resistance management strategy after 15 years of Bt crop use in North America

F Huang, DA Andow… - … Experimentalis et Applicata, 2011 - Wiley Online Library
Transgenic maize and cotton expressing Bacillus thuringiensis (Bt) toxins were first
commercialized in 1996. By 2009, Bt crops were planted on ca. 47.6 Mha in 22 countries …

Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transporter Subfamily A Protein

WT Tay, RJ Mahon, DG Heckel, TK Walsh… - PLoS …, 2015 - journals.plos.org
The use of conventional chemical insecticides and bacterial toxins to control lepidopteran
pests of global agriculture has imposed significant selection pressure leading to the rapid …

Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China

H Zhang, W Tian, J Zhao, L Jin… - Proceedings of the …, 2012 - National Acad Sciences
Evolution of pest resistance reduces the efficacy of insecticidal proteins from Bacillus
thuringiensis (Bt) used in sprays or in transgenic crops. Although several pests have evolved …