Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction
of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature …

Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Many of the key questions facing cellular biology concern the location and concentration of
chemical species, from signalling molecules to metabolites to exogenous toxins. Fluorescent …

Elemental imaging gives insight into the fundamental chemical makeup of living organisms.
Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements …

Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …

Copper is an essential metal nutrient for life that often relies on redox cycling between Cu (I)
and Cu (II) oxidation states to fulfill its physiological roles, but alterations in cellular redox …

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a feasible
technique to obtain either quantitative elemental data or spatially resolved imaging/mapping …