About 8% of our genome is composed of sequences with viral origin, namely human
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …

Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

Aging and neurodegenerative disease are characterized by genomic instability in neurons,
including aberrant activation and mobilization of transposable elements (TEs). Integrating …

Signaling mechanisms that regulate astrocyte reactivity and scar formation after spinal cord
injury (SCI) are not well defined. We used the Cre recombinase (Cre)-loxP system under …

Saffron or Crocus sativus L.(C. sativus) has been widely used as a medicinal plant to
promote human health, especially in Asia. The main components of saffron are crocin …

BACKGROUND: Patients with bipolar disorder are known to be at high risk of premature
death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well …

The ultimate form of parasitism and evasion of host immunity is for the parasite genome to
enter the germ line of the host species. Retroviruses have invaded the host germ line on the …

Multiple sclerosis (MS) is a disease of the central nervous system characterized by
inflammation, demyelination, and neuronal damage. Environmental and genetic factors are …

Reactive astrocytosis occurs prominently in response to all forms of CNS injury or disease.
The functions of reactive astrocytes are not well understood, and both harmful and beneficial …