Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

M Ileriturk, D Ileriturk, O Kandemir… - … of Biochemical and …, 2024 - Wiley Online Library
Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases.
Naringin (4′, 5, 7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of …

Melatonin mitigated methotrexate-induced hepatotoxicity through interrelated biological processes

N Abdallah, ME Amer, MA Amer, MA El-Missiry… - Molecular Biology …, 2024 - Springer
Background Hepatotoxicity associated with methotrexate (MTX) is mainly due to disruption
of redox balance and development of oxidative injury to hepatocytes. Melatonin (MLT) is a …

The beneficial effects of l‐carnitine and infliximab in methotrexate‐induced hepatotoxicity: Emphasis on Notch1/Hes‐1 signaling

SM Radwan, GA Abdel‐Latif, SS Abbas… - Archiv der …, 2023 - Wiley Online Library
Methotrexate (MTX)‐induced hepatotoxicity is a serious adverse effect that may limit its use.
Therefore, eligible drugs to ameliorate MTX‐induced hepatotoxicity are required. l‐Carnitine …

Improving Captopril cardioprotective activities against Doxorubicin induced cardiotoxicity by co-administration with allicin

EM Aboubakr, MI Rushdi… - … -International Journal of …, 2024 - svuijm.journals.ekb.eg
Background: Doxorubicin (DOX) is an anticancer drug with significant clinical implications;
however its utilization is limited due to its significant adverse effects especially on the …

[PDF][PDF] Effects of methotrexate on hepatic and testicular tissues in male rabbits: Histological, hormonal and biochemical analysis

AJ Al-Nuaimi, EJ Jabber, MJ Jawad, MS Hassan… - Iraqi Journal of …, 2023 - iasj.net
MTX is a potent cytotoxic drug with applications in cancer treatment via chemotherapy. In
addition to suppressing the immune system, methotrexate has hepatotoxic and nephrotoxic …