[HTML][HTML] Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential

H Kheraldine, O Rachid, AM Habib… - Advanced drug delivery …, 2021 - Elsevier
Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

Nanoparticles as drug delivery systems

AZ Wilczewska, K Niemirowicz, KH Markiewicz… - Pharmacological …, 2012 - Elsevier
Controlled drug delivery systems (DDS) have several advantages compared to the
traditional forms of drugs. A drug is transported to the place of action, hence, its influence on …

Endocytosis of nanomedicines

G Sahay, DY Alakhova, AV Kabanov - Journal of controlled release, 2010 - Elsevier
Novel nanomaterials are being developed to improve diagnosis and therapy of diseases
through effective delivery of drugs, biopharmaceutical molecules and imaging agents to …

Applications of dendrimers in nanomedicine and drug delivery: A review

M Nikzamir, Y Hanifehpour, A Akbarzadeh… - Journal of Inorganic and …, 2021 - Springer
Dendrimers are hyper-branched organic compounds characterized via a three-dimensional
structure possessing functional groups on the surface. These terminals groups can be …

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

AR Menjoge, RM Kannan, DA Tomalia - Drug discovery today, 2010 - Elsevier
Dendrimers are members of a versatile, fourth new class of polymer architecture (ie dendritic
polymers after traditional linear, crosslinked and branched types)[1]. Typically, dendrimers …

General overview of lipid–polymer hybrid nanoparticles, dendrimers, micelles, liposomes, spongosomes and cubosomes

RR Wakaskar - Journal of drug targeting, 2018 - Taylor & Francis
Introduction: In recent years, the wider use of nanotechnology has attracted greater attention
from scientists in multi-disciplinary fields. Nanotechnological research has come a long way …

Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery

S Sadekar, H Ghandehari - Advanced drug delivery reviews, 2012 - Elsevier
This article summarizes efforts to evaluate poly (amido amine)(PAMAM) dendrimers as
carriers for oral drug delivery. Specifically, the effect of PAMAM generation, surface charge …

Applications of dendrimers in drug delivery agents, diagnosis, therapy, and detection

B Noriega-Luna, LA Godínez… - Journal of …, 2014 - Wiley Online Library
In recent years, the application of dendrimers in biomedicine attracted much attention from
scientists. Dendrimers are interesting for biomedical applications because of their …

The effect of surface functionality on cellular trafficking of dendrimers

OP Perumal, R Inapagolla, S Kannan, RM Kannan - Biomaterials, 2008 - Elsevier
Dendrimers are an emerging group of nanostructured, polymeric biomaterials that have
potential as non-viral vehicles for delivering drugs and genetic material to intracellular …