Pesticides are important chemicals or biological agents that deter or kill pests. The use of
pesticides has continued to increase as it is still considered the most effective method to …

The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …

Abstract Coronavirus disease 2019 (Covid-19) is a novel worldwide pandemic caused by a
novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). During Covid-19 …

With respect to structural and functional cardiac disorders, heart failure (HF) is divided into
HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …

Lung cancer is the major cause of cancer associated mortality. Mutations in EGFR have
been implicated in lung cancer pathogenesis. Gefitinib (GF) is a RTKI (receptor tyrosine …

The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

The dynamic cycling of O-linked GlcNAc (O-GlcNAc) on and off Ser/Thr residues of
intracellular proteins, termed O-GlcNAcylation, is mediated by the conserved enzymes O …