Parkinson's disease (PD) is a highly heterogeneous disorder, which probably consists of
multiple subtypes. Aggregation of misfolded alpha-synuclein and propagation of these …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

The ultimate origin of Lewy body disorders, including Parkinson's disease (PD) and
Dementia with Lewy bodies (DLB), is still incompletely understood. Although a large number …

Cardiac sympathetic denervation, as documented on 123I-metaiodobenzylguanidine (MIBG)
myocardial scintigraphy, is relatively sensitive and specific for distinguishing Parkinson's …

Background Isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) is
considered as a prodromal stage of either multiple system atrophy (MSA) or Lewy body …

Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of
alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy …

Background and objective In 2004 we described the E46K mutation in alpha-synuclein gene
(E46K-SNCA), a rare point mutation causing an aggressive Lewy body disease with early …

Abstract Cardiac 123 I-metaiodobenzylguanidine (MIBG) uptake correlates with the extent of
cardiac sympathetic denervation found in disease with Lewy pathology, such as Parkinson's …

Cardiac 123I-MIBG scintigraphy is used to assess the function of postganglionic presynaptic
cardiac sympathetic nerve endings. 123I-MIBG cardiac uptake is markedly reduced in …