Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Chemotherapy is currently the main treatment for unresectable or advanced postoperative
gastric cancers. However, its efficacy is negatively affected by the occurrence of …

Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger
selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Autophagy is a tightly regulated catabolic process wherein cells under stress sequester
cytosolic constituents like damaged proteins and organelles in double-membrane vesicles …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

Mitophagy is a highly specialized process to remove dysfunctional or superfluous
mitochondria through the macroautophagy/autophagy pathway, aimed at protecting cells …

Autophagy is a conserved intracellular degradation pathway essential for protein
homeostasis, survival and development. Defects in autophagic pathways have been …

Macroautophagy is an intracellular catabolic process involved in the formation of multiple
membrane structures ranging from phagophores to autophagosomes and autolysosomes …