Major depressive disorder is an often chronic and recurring illness. Left untreated, major
depressive disorder may result in progressive alterations in brain morphometry and circuit …

Serotonin syndrome is a potentially fatal condition caused by drugs that affect serotonin
metabolism or act as serotonin receptor agonists. Monoamine oxidase inhibitors, selective …

Psychiatric and physical conditions often coexist, and there is robust evidence that
associates the frequency of depression with single and multiple physical conditions. More …

The present article reports the first liquid chromatography (LC) assay for the simultaneous
quantification of fluoxetine (FLU), its metabolite norfluoxetine (NFLU) and paroxetine (PAR) …

THE LAST DECADE has witnessed significant breakthroughs in diagnosis and management
of neuroendocrine carcinoid tumors. This field is currently one of the most dynamic areas of …

Background: The contribution of the CYP3A5 enzyme to the metabolism of clinically used
drugs has been established only for a few CYP3A substrates, such as the …

The serotonin transporter (SERT) is found in neuron and platelet membranes. Selective
serotonin-reuptake inhibitors (SSRIs) are widely prescribed for severe depression. They …

Background: Data demonstrating the real-world, long-term effectiveness of vortioxetine in
elderly patients with major depressive disorder (MDD) are clinically useful to confirm …

Carcinoid tumors are neuroendocrine tumors with a very unpredictable clinical behavior. In
the setting of hepatic metastases, the tumor's release of bioactive substances into the …

Patients with clinical diseases often present psychiatric conditions whose pharmacological
treatment is hampered due to hazardous interactions with the clinical treatment and/or …