The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …

The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …

The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to
understand the molecular processes of infection. Related flaviviruses produce noncoding …

Ribozymes are noncoding RNAs that promote chemical transformations with rate
enhancements approaching those of protein enzymes. Although ribozymes are likely to …

Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA
processing. However, such natural ribozymes are exceedingly rare, as evidenced by the fact …

Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that
depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry …

The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-)
cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three …

Hepatitis D virus (HDV) forms the genus Deltavirus unassigned to any virus family. HDV is a
satellite virus and needs hepatitis B virus (HBV) to make infectious particles. Deltaviruses …

Hepatitis delta virus (HDV) is a human hepatitis-causing RNA virus, unrelated to any other
taxonomic group of RNA viruses. Its occurrence as a satellite virus of hepatitis B virus (HBV) …

Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus
Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging …