Gut microbiota in colorectal cancer development and therapy
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
Epigenetic regulation by gut microbiota
V Woo, T Alenghat - Gut microbes, 2022 - Taylor & Francis
The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …
collectively termed the microbiota, which are environmental stimuli that can direct health and …
Host–microbiota maladaptation in colorectal cancer
A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
Early-onset colorectal cancer: initial clues and current views
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration
While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
The microbiome and gynaecological cancer development, prevention and therapy
P Łaniewski, ZE Ilhan, MM Herbst-Kralovetz - Nature Reviews Urology, 2020 - nature.com
The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …
microbiome, which has an essential role in maintaining health and homeostasis. In the …
Wnt signaling pathway in cancer immunotherapy
Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …
[HTML][HTML] Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer
SL Zhang, YQ Mao, ZY Zhang, ZM Li, CY Kong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Anti-PD-1-based immunotherapy has emerged as a promising therapy for
several cancers. However, it only benefits a small subset of colorectal cancer (CRC) …
several cancers. However, it only benefits a small subset of colorectal cancer (CRC) …
New insights into the cancer–microbiome–immune axis: decrypting a decade of discoveries
The past decade has witnessed groundbreaking advances in the field of microbiome
research. An area where immense implications of the microbiome have been demonstrated …
research. An area where immense implications of the microbiome have been demonstrated …