I. OVERVIEW AND NOMENCLATURE Times change. In 1926, the writer of a review in this
journal noted that over 350 papers had appeared on the subject during the previous 2 years …

The hippocampal pyramidal cells provide an example of how multiple potassium (K)
currents co-exist and function in central mammalian neurones. The data come from CA1 and …

Voltage-activated K+ currents and their inactivation properties are important for controlling
frequencydependent signaling in neurons and other excitable cells. Two distinct molecular …

Responses of excitatory amino acid receptors to rapidly applied glutamate were measured
in outside-out membrane patches from chick spinal neurons. The peak current varied with …

Substitution of a cysteine in the extracellular mouth of the pore of the Shaker-delta K+
channel permits allosteric inhibition of the channel by Zn2+ or Cd2+ ions at micromolar …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

The ligand binding domain (LBD) of the nicotinic acetylcholine receptor has served as a
prototype for understanding molecular recognition in the family of neurotransmitter‐gated …

Several calcium-dependent potassium currents can contribute to the electrophysiological
properties of neurons. In hippocampal pyramidal cells, 2 afterhyperpolarizations (AHPs) are …

This chapter reviews properties and functions of endogenous ionic currents in hippocampal
neurones. Currents considered are: Na currents I Na (fast) and I Na (slow); Ca currents; K …

At a synapse, the transmitter is stored in synaptic vesicles and is released into the synaptic
cleft almost instantaneously upon fusion of these vesicles with the presynaptic membrane …