Network pharmacology and in vitro validation to elucidate the molecular mechanism of Boswellia serrata phytoconstituents on inflammation

MR Barik, H Kaur, T Amin, H Tiwari, G Kour… - Journal of Proteins and …, 2024 - Springer
Boswellia serrata is a popular medicinal plant used to treat various inflammatory diseases.
However, its molecular mechanism for treating inflammation is still unknown. In this study, a …

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

M Petrosino, L Novak, A Pasquo, P Turina, E Capriotti… - Human Genomics, 2023 - Springer
Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular
regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by …

Biochemical characterization of the Drosophila insulin receptor kinase and longevity‐associated mutants

H Krishnan, S Ahmed, SR Hubbard… - The FASEB …, 2024 - Wiley Online Library
Drosophila melanogaster (fruit fly) insulin receptor (D‐IR) is highly homologous to the
human counterpart. Like the human pathway, D‐IR responds to numerous insulin‐like …