International Expert Consensus on Switching Platelet P2Y12 Receptor–Inhibiting Therapies

DJ Angiolillo, F Rollini, RF Storey, DL Bhatt, S James… - Circulation, 2017 - Am Heart Assoc
Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor is the treatment of choice for the
prevention of atherothrombotic events in patients with acute coronary syndromes and for …

The management of antithrombotic agents for patients undergoing GI endoscopy

RD Acosta, NS Abraham… - Gastrointestinal …, 2016 - giejournal.org
This is one of a series of statements discussing the use of GI endoscopy in common clinical
situations. The Standards of Practice Committee of the American Society for Gastrointestinal …

Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) …

G Parodi, R Valenti, B Bellandi, A Migliorini… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to compare the action of prasugrel and ticagrelor in ST-
segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous …

Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment–elevation myocardial infarction

D Alexopoulos, I Xanthopoulou, V Gkizas… - Circulation …, 2012 - Am Heart Assoc
Background—Ticagrelor and prasugrel provide stronger platelet inhibition compared with
clopidogrel. Direct pharmacodynamic comparison between them has not yet been reported …

Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease

JL Mega, W Hochholzer, AL Frelinger, MJ Kluk… - Jama, 2011 - jamanetwork.com
Context Variants in the CYP2C19 gene influence the pharmacologic and clinical response
to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. Objective …

Switching P2Y12-receptor inhibitors in patients with coronary artery disease

F Rollini, F Franchi, DJ Angiolillo - Nature Reviews Cardiology, 2016 - nature.com
Dual antiplatelet therapy—the combination of aspirin and a P2Y 12-receptor inhibitor—is the
cornerstone of treatment of patients with acute coronary syndromes (ACS) and of those …

Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a …

D Alexopoulos, A Galati, I Xanthopoulou… - Journal of the American …, 2012 - jacc.org
Objectives: The study aimed to compare the antiplatelet action of ticagrelor with prasugrel in
acute coronary syndrome (ACS) patients with high on-treatment platelet reactivity (HTPR) …

Proton pump inhibitors: potential adverse effects

NS Abraham - Current opinion in gastroenterology, 2012 - journals.lww.com
Proton pump inhibitors: potential adverse effects : Current Opinion in Gastroenterology Proton
pump inhibitors: potential adverse effects : Current Opinion in Gastroenterology Log in or …

The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day

DJ Angiolillo - Drugs, 2012 - Springer
Our knowledge of the mechanisms of platelet-mediated thrombosis has increased
dramatically over the last 40 years. This increased understanding has identified treatment …

Morphine decreases ticagrelor concentrations but not its antiplatelet effects: a randomized trial in healthy volunteers

EL Hobl, B Reiter, C Schoergenhofer… - European journal of …, 2016 - Wiley Online Library
Background Our recent drug interaction trial with clopidogrel shows that morphine
decreases the concentrations and pharmacodynamic effects of clopidogrel, which could …