Bursting is one of the fundamental rhythms that excitable cells can generate either in
response to incoming stimuli or intrinsically. It has been a topic of intense research in …

Despite intense research, few treatments are available for most neurological disorders.
Demyelinating diseases are no exception. This is perhaps not surprising considering the …

Ionic concentrations fluctuate significantly during epileptic seizures. In this study, using a
combination of in vitro electrophysiology, computer modeling, and dynamical systems …

Axons reliably conduct action potentials between neurons and/or other targets. Axons have
widely variable diameters and can be myelinated or unmyelinated. Although the effect of …

Central pattern generators (CPGs), specialized oscillatory neuronal networks controlling
rhythmic motor behaviors such as breathing and locomotion, must adjust their patterns of …

When neurons fire action potentials, dissipation of free energy is usually not directly
considered, because the change in free energy is often negligible compared to the immense …

Normal axon development depends on the action of mechanical forces both generated
within the cytoskeleton and outside the cell, but forces of large magnitude or rate cause …

The brain primarily relies on glycolysis for mitochondrial respiration but switches to
alternative fuels such as ketone bodies (KBs) when less glucose is available. Neuronal KB …

Diffusion imaging and postmortem studies of patients with mild traumatic brain injury (mTBI)
of the concussive type are consistent with the observations of diffuse axonal injury to the …

Axonal conduction velocity can change substantially during ongoing activity, thus modifying
spike interval structures and, potentially, temporal coding. We used a biophysical model to …