The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Patients with type 2 diabetes (T2D) are at increased risk for cardiovascular diseases
including diabetic cardiomyopathy, which is ventricular dysfunction independent of …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Phospholipids represent a crucial component for the structure of cell membranes.
Phosphatidylcholine and phosphatidylethanolamine are two phospholipids that comprise …

The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty
acids. Monounsaturated fatty acids limit the toxicity of exogenous saturated fats. Studies …

Aims Circadian rhythms are important for healthy cardiovascular physiology and they are
regulated by the molecular circadian mechanism. Previously, we showed that disruption of …

Cerebral choline metabolism is crucial for normal brain function, and its homoeostasis
depends on carrier-mediated transport. Here, we report on four individuals from three …

Alzheimer's disease (AD) is a main cause of dementia and exhibits abnormality in cognitive
behaviors. Here, we probed into the role of p75 neurotrophin receptor (p75NTR) in cognitive …

Highlights•Circadian rhythms are important for cardiovascular physiology; disturbing
rhythms causes adverse cardiovascular consequences.•Circadian medicine is a new frontier …