Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and
contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide …

The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and
dependence. Resistance exercise (RE) is an effective rehabilitation technique that can …

Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

Exercise is associated with increased ATP need and an enhanced aerobic and/or anaerobic
metabolism, which results in an increased formation of reactive oxygen species (ROS) …

Healthy aging can be promoted by enhanced metabolic fitness and physical capacity.
Mitochondria are chief metabolic organelles with strong implications in aging that also …