Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Abstract Site-Directed Spin Labelling (SDSL) technique is based on the attachment of a
paramagnetic label onto a specific position of a protein (or other bio-molecules) and the …

Distance distribution information obtained by pulsed dipolar EPR spectroscopy provides an
important contribution to many studies in structural biology. Increasingly, such information is …

Kinesin motors power many motile processes by converting ATP energy into unidirectional
motion along microtubules. The force-generating and enzymatic properties of conventional …

Site-direct spin labeling combined with electron paramagnetic resonance (EPR)
spectroscopy is a powerful tool for detecting structural changes in proteins. This review …

A remarkable feature of prion biology is the strain phenomenon wherein prion particles
apparently composed of the same protein lead to phenotypically distinct transmissible …

In mechanosensitive (MS) channels, gating is initiated by changes in intra-bilayer pressure
profiles originating from bilayer deformation. Here we evaluated two physical mechanisms …

To test whether distances derived from paramagnetic broadening of 15N heteronuclear
single quantum coherence (HSQC) resonances could be used to determine the global fold …

Site-directed spin labeling of proteins is experiencing a phase of rapid technical evolution,
application and evaluation. New strategies have been introduced for determining membrane …

Despite the rapid pace of new protein structure determination by NMR and crystallographic
means, structural problems remain that are generally inaccessible to these powerful …