Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

Research on nano-armored bacterial materials (NABM) has attracted considerable attention
because of their ability to exert synergistic effects on bacteria and nanomaterials through …

Radiotherapy (RT) triggers immunogenic cell death (ICD). L-ASNase, which catalyzes the
conversion of asparagine (Asn), thereby depleting it, is used in the treatment of blood …

Despite the tremendous progress in cancer treatment in recent decades, cancers often
become resistant due to multiple mechanisms, such as intrinsic or acquired multidrug …

Inflammatory bowel disease (IBD) is a kind of auto-immune disease characterized by
disrupted intestinal barrier and mucosal epithelium, imbalanced gut microbiome and …

Cancer therapy remains a critical medical challenge. Immunotherapy is an emerging
approach to regulating the immune system to fight cancer and has shown therapeutic …

Immunotherapy has revolutionized the treatment of cancer but continues to be constrained
by limited response rates, acquired resistance, toxicities and high costs, which necessitates …

The major reason for the failure of conventional therapies is the heterogeneity and
complexity of tumor microenvironments (TMEs). Many malignant tumors reprogram their …

Conventional cancer therapies have many limitations. In the last decade, it has been
suggested that bacteria-mediated immunotherapy may circumvent the restrictions of …

Immunotherapy with checkpoint blockade has shown remarkable efficacy in many patients
with a variety of different types of cancer. However, the majority of patients with cancer have …