Shigella spp. are a common cause of diarrheal disease and have remained an important
pathogen responsible for increased rates of morbidity and mortality caused by dysentery …

Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal
RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's …

Acute diarrheal infections are a common health problem globally and among both
individuals in the United States and traveling to developing world countries. Multiple …

Background Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is
typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since …

From its introduction in 1952 onwards, the clinical use of macrolides has been steadily
increasing, both in human and veterinary medicine. Although initially designed to the …

Background Azithromycin (AZM), sold under the name Zithromax, is classified as a
macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and …

Background Enteric pathogens are often associated with exposure to food, water, animals,
and feces from infected individuals. However, in sexual networks of men who have sex with …

Whole-genome sequencing has enhanced surveillance and facilitated detailed monitoring
of the transmission of Shigella species in England. We undertook an epidemiological and …

Annually, Shigella spp. cause≈ 188 million cases of diarrheal disease globally, including
500,000 cases in the United States; rates of antimicrobial resistance are increasing. To …

Abstract Shigella spp. cause≈ 500,000 illnesses in the United States annually, and
resistance to ciprofloxacin, ceftriaxone, and azithromycin is emerging. We investigated …