The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …

The orexin (hypocretin) system comprises two neuropeptides (orexin-A and orexin-B) and
two G-protein coupled receptors (the orexin type 1 and the orexin type 2 receptor). The …

Social stress, a common stressor, causes multiple forms of physical and mental dysfunction.
Prolonged exposure to social stress is associated with a higher risk of psychological …

Stress-related disorders, such as mood disorders and posttraumatic stress disorder (PTSD),
are more common in women than in men. This sex difference is at least partly due to the …

Twenty-five years have passed since the discovery of the orexin system, during which time
we have learned more and more about it. A number of studies have been conducted …

The orexin/hypocretin receptor type 1 (OX1R) plays a crucial role in regulating various
physiological functions, especially feeding behavior, addiction, and reward. Genetic …

Despite progress in understanding the pathological mechanisms underlying psychiatric
disorders, translation from animal models into clinical use remains a significant bottleneck …

Orexins are hypothalamic neuropeptides regulating a range of behaviors broadly associated
with sleep, motivation, and feeding. These responses highlight the importance of orexins in …

Orexin A and B, also known as hypocretin 1 and 2, are excitory neuropeptides synthesized
in the perifornical and lateral hypothalamic areas. Following their discovery in 1998, orexins …