Growth hormone (GH) research and its clinical application for the treatment of growth
disorders span more than a century. During the first half of the 20th century, clinical …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing
hormonal demands throughout life. There is circumstantial evidence that multipotent adult …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Living organisms represent, in essence, dynamic interactions of high complexity between
membrane‐separated compartments that cannot exist on their own, but reach behaviour in …

Non‐Technical Summary The islet of Langerhans secretes the hormone insulin in response
to elevated glucose. Interactions between cells within the islet is important for the regulation …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

This article reviews the main findings that emerged in the intervening years since the
previous volume on hormonal control of growth in the section on the endocrine system of the …

Both endocrine and non-endocrine cells of the pituitary gland are organized into structural
and functional networks which are formed during embryonic development but which may be …