Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

The Chilean soapbark tree (Quillaja saponaria) produces soap-like molecules called QS
saponins that are important vaccine adjuvants. These highly valuable compounds are …

QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean
soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus …

Mycobacteria have a unique cell wall, which is rich in drug targets. The cell wall core
consists of a peptidoglycan layer, a mycolic acid layer, and an arabinogalactan …

Glycosylation is a key mechanism for orchestrating the bioactivity, metabolism and location
of small molecules in living cells. In plants, a large multigene family of glycosyltransferases …

Mass spectrometry is the primary analytical technique used to characterize the complex
oligosaccharides that decorate cell surfaces. Monosaccharide building blocks are often …

Nucleotide sugars play an elementary role in nature as building blocks of glycans,
polysaccharides, and glycoconjugates used in the pharmaceutical, cosmetics, and food …

Glycans and glycosylated biomolecules are directly involved in almost every biological
process as well as the etiology of most major diseases. Hence, glycoscience knowledge is …

Fluorinated carbohydrates, where one (or more) fluorine atom (s) have been introduced into
a carbohydrate structure, typically through deoxyfluorination chemistry, have a wide range of …

While target-based drug design has proved successful in several therapeutic areas, this
approach has not yet provided compelling outcomes in the field of antibacterial agents. This …