Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Pancreatic ductal adenocarcinoma (PDA), the most frequent type of pancreatic cancer,
remains one of the most challenging problems for the biomedical and clinical fields, with …

Galectins are a family of small, highly conserved, molecular effectors that mediate various
biological processes, including chemotaxis and angiogenesis, and that function by …

The immune system plays a crucial role in the regulation of metastasis. Tumor cells
systemically change immune functions to facilitate metastatic progression. Through this …

Scavenger receptors constitute a large family of evolutionally conserved protein molecules
that are structurally and functionally diverse. Although scavenger receptors were originally …

Sorafenib, a small-molecule inhibitor targeting several tyrosine kinase pathways, is the
standard treatment for advanced hepatocellular carcinoma (HCC). However, not all patients …

Prostate cancer is the most common cancer in men and a major cause of cancer related
deaths worldwide. Nearly all affected men develop resistance to current therapies and there …