Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

The acidic pH of tumors profoundly inhibits effector functions of activated CD8+ T-cells. We
hypothesize that this is a physiological process in immune regulation, and that it occurs …

Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are
features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact …

Communication, the effective delivery of information, is fundamental to life across all scales
and species. Nervous systems (by necessity) may be most specifically adapted among …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …

To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of
myeloid cells, in particular monocytes and dendritic cells. However, the timing and …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …