In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

Diabetes belongs to a group of metabolic disorders characterized by long term high blood
glucose levels due to either inadequate production of insulin (Type 1 diabetes, T1DM) or …

In this perspective, we provide an overview of a recently established National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas …

It is important to find better treatments for diabetic nephropathy (DN), a debilitating renal
complication. Targeting early features of DN, including renal extracellular matrix …