Biology and therapeutic targeting of vascular endothelial growth factor A
L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
Vascular endothelial growth factor signaling in development and disease
S Karaman, VM Leppänen, K Alitalo - Development, 2018 - journals.biologists.com
Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …
orchestrating the development and maintenance of the blood and lymphatic vascular …
Structural basis of the activation of c-MET receptor
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
Hypoxia and hypoxia-inducible factors in kidney injury and repair
S Shu, Y Wang, M Zheng, Z Liu, J Cai, C Tang, Z Dong - Cells, 2019 - mdpi.com
Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …
[HTML][HTML] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
Corneal neovascularization
MP Nicholas, N Mysore - Experimental eye research, 2021 - Elsevier
The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal
neovascularization, which is a major cause of vision loss worldwide, leads to corneal …
neovascularization, which is a major cause of vision loss worldwide, leads to corneal …
Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …
PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …
Structural insights into the assembly of gp130 family cytokine signaling complexes
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or
heterodimerization with a second signaling receptor and play crucial roles in various cellular …
heterodimerization with a second signaling receptor and play crucial roles in various cellular …
Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …