It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

The emergence of immunotherapy has been an astounding breakthrough in cancer
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …

Epstein-Barr virus (EBV), a gamma-1 herpesvirus, is carried as a life-long asymptomatic
infection by the great majority of individuals in all human populations. Yet this seemingly …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

The immunosuppressive tumor microenvironment represents not only one of the key factors
stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and
escape from immunity via T cell suppression. Initially, these myeloid cells were identified as …

The immune landscape of a tumor is highly connected to patient prognosis and response to
treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …