The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …

Compounds featuring aziridine moieties are widely known and extensively reported in the
literature. Due to their great potential from both synthetic and pharmacological points of …

COVID-19 now ranks among the most devastating global pandemics in history. The
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …

This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …

The ubiquitin‐proteasome pathway (UPP) represents the principal proteolytic apparatus in
the cytosol and nucleus of all eukaryotic cells. Nowadays, proteasome inhibitors (PIs) are …

In recent decades, many efforts have been devoted to studying reactions catalyzed in
nanoconfined spaces. The most impressive aspect of catalysis in nanoconfined spaces is …

This is the first Editorial of the “Molecular Informatics” Section (MIS) of the International
Journal of Molecular Sciences (IJMS), which was created towards the end of 2018 (the first …

Abstract The Main Protease (Mpro) plays a pivotal role in the replication of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved …

SARS-CoV-2 attachment and entry inside mammalian cells is mainly mediated by human
angiotensin-converting enzyme 2 (ACE2) and its interaction with spike protein. However, it is …

Since their introduction in the synthetic toolbox, lithium carbenoids were considered
versatile C‐1 donor agents, thus enabling selective insertion processes within preformed X …