Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Over the last two decades, mass spectrometry imaging (MSI) has been increasingly
employed to investigate the spatial distribution of a wide variety of molecules in complex …

Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic
resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually …

Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI)
permits label-free in situ analysis of chemical compounds directly from the surface of two …

Imaging mass spectrometry (IMS) is a powerful analytical technique widely used in biology,
chemistry, and materials science fields that continue to expand. IMS provides a qualitative …

Mass spectrometry imaging has advanced from a niche technique to a widely applied spatial
biology tool operating at the forefront of numerous fields, most notably making a significant …

Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and
strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several …

A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the
absence of significant thermal damage. As such, PIRL is a standalone surgical scalpel with …