Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Y Zhang, Q Li, Z Huang, B Li, EC Nice, C Huang, L Wei… - Cancers, 2022 - mdpi.com
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Evolutionary Game Theory: Darwinian Dynamics and the G Function Approach

A Bukkuri, JS Brown - Games, 2021 - mdpi.com
Classical evolutionary game theory allows one to analyze the population dynamics of
interacting individuals playing different strategies (broadly defined) in a population. To …

Artificial intelligence in clinical oncology: from data to digital pathology and treatment

K Senthil Kumar, V Miskovic, A Blasiak… - American Society of …, 2023 - ascopubs.org
Recently, a wide spectrum of artificial intelligence (AI)–based applications in the broader
categories of digital pathology, biomarker development, and treatment have been explored …

Coordination games in cancer

P Bayer, RA Gatenby, PH McDonald, DR Duckett… - PLoS …, 2022 - journals.plos.org
We propose a model of cancer initiation and progression where tumor growth is modulated
by an evolutionary coordination game. Evolutionary games of cancer are widely used to …

Integrating eco‐evolutionary dynamics into matrix population models for structured populations: Discrete and continuous frameworks

A Bukkuri, JS Brown - Methods in Ecology and Evolution, 2023 - Wiley Online Library
State‐structured populations are ubiquitous in biology, from the age‐structure of animal
societies to the life cycles of parasitic species. Understanding how this structure contributes …

Photochemically Controlled Release of the Glucose Transporter 1 Inhibitor for Glucose Deprivation Responses and Cancer Suppression Research

H Geng, L Chen, SW Lv, M Li, X Huang… - Journal of Proteome …, 2024 - ACS Publications
Cancer cells need a greater supply of glucose mainly due to their aerobic glycolysis, known
as the Warburg effect. Glucose transport by glucose transporter 1 (GLUT1) is the rate-limiting …

Combinatorial MD/QM studies to develop novel ionic liquid-based anticancer drug delivery systems with aminium derived from carbohydrates as cationic components

S Kalhor, A Fattahi - Scientific Reports, 2024 - nature.com
The main challenges in anticancer drug design include solubility in organic and aqueous
phases, bioavailability, selective targeting of specific receptors, and low toxicity. Notably …

Modeling cancer's ecological and evolutionary dynamics

A Bukkuri, KJ Pienta, I Hockett, RH Austin… - Medical Oncology, 2023 - Springer
In this didactic paper, we present a theoretical modeling framework, called the G-function,
that integrates both the ecology and evolution of cancer to understand oncogenesis. The G …

Public Goods Games in Disease Evolution and Spread

C Morison, M Fic, T Marcou… - arXiv preprint arXiv …, 2024 - arxiv.org
Cooperation arises in nature at every scale, from within cells to entire ecosystems. In the
framework of evolutionary game theory, public goods games (PGGs) are used to analyse …

Biomarkers or biotargets? Using competition to lure cancer cells into evolutionary traps

A Bukkuri, FR Adler - Evolution, Medicine, and Public Health, 2023 - academic.oup.com
Abstract Background and Objectives Cancer biomarkers provide information on the
characteristics and extent of cancer progression and help inform clinical decision-making …