Induction of intrinsic liver regeneration is an unmet need that can be achieved by temporally
activating key hepatocyte regenerative pathways. Here, we establish an efficient, safe, non …

Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of
cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but …

The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of
Injury to Modulation of Disease”(referred to as SFB/TRR57) was funded for 13 years (2009 …

Non‐alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of
histopathological changes ranging from non‐inflammatory intracellular fat deposition to non …

Equilibration of metal metabolism is critical for normal liver function. Most epidemiological
studies have only concentrated on the influence of limited metals. However, the single and …

Metabolic factors are the major risk of non-alcoholic fatty liver disease, although other factors
may contribute steatosis. Cadmium exposure produces histopathological and molecular …

Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype
due to its lack of targeted therapies and poor prognosis. In order to treat patients with these …

Primary liver cancers represent the second leading cause of cancer-related deaths
worldwide. Diverse etiological factors include chronic viral hepatitis, aflatoxin and alcohol …

Nonalcoholic steatohepatitis is one of the leading causes of liver disease. Dietary factors
determine the clinical presentation of steatohepatitis and can influence the progression of …

The liver neutralizes endogenous and exogenous toxins and metabolites, being
metabolically interconnected with many organs. Numerous clinical and experimental studies …