The immense majority of genes are alternatively spliced and there are many isoforms
specifically associated with cancer progression and metastasis. The splicing pattern of …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …

Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as
optical, electronic and magnetic materials, coatings, additives, supramolecular chemistry …

Alternative splicing is a key mechanism determinant for gene expression in metazoan.
During alternative splicing, non-coding sequences are removed to generate different mature …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

More than 95% of genes in the human genome are alternatively spliced to form multiple
transcripts, often encoding proteins with differing or opposing function. The control of …

Aminoacyl-tRNA synthetases classically regulate protein synthesis but some also engage in
alternative signaling functions related to immune responses and angiogenesis. Threonyl …

Over two dozen spliceosome proteins are involved in human diseases, also referred to as
spliceosomopathies. WW domain-binding protein 4 (WBP4) is part of the early spliceosomal …

Malaria remains a major global health problem. Emerging resistance to existing antimalarial
drugs drives the search for new antimalarials, and protein translation is a promising pathway …

Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by
alternative splicing. Two families of isoforms have been described in humans, pro …