Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways
T Jin, Y Zhang, BOA Botchway, J Zhang, R Fan… - Food and Chemical …, 2022 - Elsevier
Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …
Treatment with the flavonoid 7, 8-Dihydroxyflavone: A promising strategy for a constellation of body and brain disorders
M Emili, S Guidi, B Uguagliati, A Giacomini… - Critical Reviews in …, 2022 - Taylor & Francis
Flavonoids have long been known to exert benefits in various health problems. Among
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …
Astragaloside IV prevents Aβ1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway
X Wang, W Xu, H Chen, W Li, W Li, G Zhu - Brain Research, 2020 - Elsevier
Abstract Astragaloside IV (AS-IV), a natural product derived from Radix Astragali (Astragalus
membranaceus), is beneficial for the treatment of Alzheimer's disease (AD), but the …
membranaceus), is beneficial for the treatment of Alzheimer's disease (AD), but the …
Brain-derived neurotrophic factor mimetic, 7, 8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing
Z Wang, S Wang, Q Shao, P Li, Y Sun, L Luo… - Free Radical Biology …, 2019 - Elsevier
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …
The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis
RR Kraemer, BR Kraemer - Frontiers in Endocrinology, 2023 - frontiersin.org
Over the last decade, a considerable amount of new data have revealed the beneficial
effects of exercise on hippocampal neurogenesis and the maintenance or improvement of …
effects of exercise on hippocampal neurogenesis and the maintenance or improvement of …
Activation of cardiac TrkB receptor by its small molecular agonist 7, 8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial …
J Zhao, J Du, Y Pan, T Chen, L Zhao, Y Zhu… - Free Radical Biology …, 2019 - Elsevier
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB)
pathway has been revealed as a novel therapeutic target for several neurological diseases …
pathway has been revealed as a novel therapeutic target for several neurological diseases …
Suggesting 7, 8-dihydroxyflavone as a promising nutraceutical against CNS disorders
R Paul, J Nath, S Paul, MK Mazumder… - Neurochemistry …, 2021 - Elsevier
dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine
kinase receptor B (TrkB) agonist and a bioactive molecule of therapeutic interest for …
kinase receptor B (TrkB) agonist and a bioactive molecule of therapeutic interest for …
BDNF and lactate as modulators of hippocampal CA3 network physiology
Growing evidence supports the notion that brain-derived neurotrophic factor (BDNF) and
lactate are potent modulators of mammalian brain function. The modulatory actions of those …
lactate are potent modulators of mammalian brain function. The modulatory actions of those …
Selective vulnerability of hippocampal CA1 and CA3 pyramidal cells: What are possible pathomechanisms and should more attention be paid to the CA3 region in …
AM Einenkel, A Salameh - Journal of Neuroscience Research, 2024 - Wiley Online Library
Transient ischemia and reperfusion selectively damage neurons in brain, with hippocampal
pyramidal cells being particularly vulnerable. Even within hippocampus, heterogeneous …
pyramidal cells being particularly vulnerable. Even within hippocampus, heterogeneous …
Functional expression of TrkB receptors on interneurones and pyramidal cells of area CA3 of the rat hippocampus
E Griego, G Herrera-López, G Gómez-Lira… - …, 2021 - Elsevier
The dentate gyrus and hippocampal area CA3 region of the mammalian brain contains the
highest levels of brain-derived neurotrophic factor (BDNF) and its canonical membrane …
highest levels of brain-derived neurotrophic factor (BDNF) and its canonical membrane …